SCOPe 2.05: Domain d4cbyd_: 4cby D:

Lineage for d4cbyd_ (4cby D:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein automated matches [190786] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188039] (24 PDB entries)

8. Domain d4cbyd_: 4cby D: [234300]
   automated match to d4cbya_
   complexed with kee, na, zn

Details for d4cbyd_

PDB Entry: 4cby, 2.72 Å

PDB Description: design, synthesis, and biological evaluation of potent and selective class iia hdac inhibitors as a potential therapy for huntington's disease

PDB Compounds: (D:) Histone deacetylase 4

SCOPe Domain Sequences for d4cbyd_:

Sequence; same for both SEQRES and ATOM records:

>d4cbyd_ c.42.1.2 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ttglvydtlmlkhqctcgsssshpehagriqsiwsrlqetglrgkcecirgrkatleelq
tvhseahtllygtnpanrqkldskkllgslasvfvrlpcggvgvdsdtiwnevhsagaar
lavgcvvelvfkvatgelkngfavvrppghhaeestpmgfcyfnsvavaakllqqrlsvs
kilivdwdvhhgngtqqafysdpsvlymslhryddgnffpgsgapdevgtgpgvgfnvnm
aftggldppmgdaeylaafrtvvmpiasefapdvvlvssgfdaveghptplggynlsarc
fgyltkqlmglaggrivlalegghdltaicdaseacvsallgneldplpekvlqqrpnan
avrsmekvmeihskywrclqrhh

Timeline for d4cbyd_:

• d4cbyd_ first appeared in SCOPe 2.03
  
• d4cbyd_ appears in SCOPe 2.04
  
• d4cbyd_ is called d4cbyd1 in SCOPe 2.06
  
• d4cbyd_ appears in the current release, SCOPe 2.08, called d4cbyd1