SCOPe 2.06: Domain d4anla_: 4anl A:

Lineage for d4anla_ (4anl A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)

8. Domain d4anla_: 4anl A: [234086]
   automated match to d4foda_
   mutant

Details for d4anla_

PDB Entry: 4anl, 1.7 Å

PDB Description: structure of g1269a mutant anaplastic lymphoma kinase

PDB Compounds: (A:) ALK tyrosine kinase receptor

SCOPe Domain Sequences for d4anla_:

Sequence, based on SEQRES records:

>d4anla_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktlp
evcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrp
rpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakiadfgm
ardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsk
snqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvi
ntalpieyg

Sequence, based on observed residues (ATOM records):

>d4anla_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pnycfagktssisdlkevprknitlirglgafgevyegqvplqvavktlpevcseqdeld
flmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakiadfgmardiyrggca
mlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmd
ppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg

Timeline for d4anla_:

• d4anla_ first appeared in SCOPe 2.03
  
• d4anla_ appears in SCOPe 2.05
  
• d4anla_ appears in SCOPe 2.07
  
• d4anla_ appears in the current release, SCOPe 2.08