Lineage for d3w2qa1 (3w2q A:698-1017)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2543502Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2543503Species Human (Homo sapiens) [TaxId:9606] [82796] (103 PDB entries)
    Uniprot P00533 702-1018
  8. 2543516Domain d3w2qa1: 3w2q A:698-1017 [233922]
    Other proteins in same PDB: d3w2qa2
    automated match to d3w2oa_
    complexed with hki, mes; mutant

Details for d3w2qa1

PDB Entry: 3w2q (more details), 2.2 Å

PDB Description: EGFR kinase domain T790M/L858R mutant with HKI-272
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d3w2qa1:

Sequence, based on SEQRES records: (download)

>d3w2qa1 d.144.1.7 (A:698-1017) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkvp
ikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqpp
ictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnf
yralmdeedmddvvdadeyl

Sequence, based on observed residues (ATOM records): (download)

>d3w2qa1 d.144.1.7 (A:698-1017) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkvp
ikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqpp
ictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspmddvv
dadeyl

SCOPe Domain Coordinates for d3w2qa1:

Click to download the PDB-style file with coordinates for d3w2qa1.
(The format of our PDB-style files is described here.)

Timeline for d3w2qa1:

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Domains from same chain:
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d3w2qa2