SCOPe 2.07: Domain d3uuoa_: 3uuo A:

Lineage for d3uuoa_ (3uuo A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.0: automated matches [191566] (1 protein)
   not a true family

6. Protein automated matches [190983] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188676] (136 PDB entries)

8. Domain d3uuoa_: 3uuo A: [233803]
   automated match to d3wi2a_
   complexed with 0cv, mg, po4, zn

Details for d3uuoa_

PDB Entry: 3uuo, 2.11 Å

PDB Description: The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia

PDB Compounds: (A:) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

SCOPe Domain Sequences for d3uuoa_:

Sequence; same for both SEQRES and ATOM records:

>d3uuoa_ a.211.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrfimsvkknyrrvpy
hnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfsnsylqkfdhplaa
lyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatdlalyfgnrkq
leemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaegdemk
klgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepllkacrdnlsqwek
virge

Timeline for d3uuoa_:

• d3uuoa_ first appeared in SCOPe 2.03
  
• d3uuoa_ appears in SCOPe 2.06
  
• d3uuoa_ appears in the current release, SCOPe 2.08