Lineage for d3uuoa_ (3uuo A:)

  1. Root: SCOPe 2.08
  2. 2685877Class a: All alpha proteins [46456] (290 folds)
  3. 2736615Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 2736616Superfamily a.211.1: HD-domain/PDEase-like [109604] (9 families) (S)
  5. 2737183Family a.211.1.0: automated matches [191566] (1 protein)
    not a true family
  6. 2737184Protein automated matches [190983] (12 species)
    not a true protein
  7. 2737203Species Human (Homo sapiens) [TaxId:9606] [188676] (139 PDB entries)
  8. 2737284Domain d3uuoa_: 3uuo A: [233803]
    automated match to d3wi2a_
    complexed with 0cv, mg, po4, zn

Details for d3uuoa_

PDB Entry: 3uuo (more details), 2.11 Å

PDB Description: The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia
PDB Compounds: (A:) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

SCOPe Domain Sequences for d3uuoa_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3uuoa_ a.211.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrfimsvkknyrrvpy
hnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfsnsylqkfdhplaa
lyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatdlalyfgnrkq
leemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaegdemk
klgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepllkacrdnlsqwek
virge

SCOPe Domain Coordinates for d3uuoa_:

Click to download the PDB-style file with coordinates for d3uuoa_.
(The format of our PDB-style files is described here.)

Timeline for d3uuoa_: