SCOPe 2.04: Domain d3t06a2: 3t06 A:942-1081

Lineage for d3t06a2 (3t06 A:942-1081)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
   barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix

4. Superfamily b.55.1: PH domain-like [50729] (14 families)

5. Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins)
   Pfam PF00169

6. Protein Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117255] (3 PDB entries)
   Uniprot O15085 714-1081

8. Domain d3t06a2: 3t06 A:942-1081 [233655]
   Other proteins in same PDB: d3t06a1, d3t06b_, d3t06e1, d3t06f_
   automated match to d1xcga2

Details for d3t06a2

PDB Entry: 3t06, 2.84 Å

PDB Description: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal regulatory elements in complex with human rhoa

PDB Compounds: (A:) Rho guanine nucleotide exchange factor 11

SCOPe Domain Sequences for d3t06a2:

Sequence, based on SEQRES records:

>d3t06a2 b.55.1.1 (A:942-1081) Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF {Human (Homo sapiens) [TaxId: 9606]}
atalerasnplaaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqde
klllkchsktavgssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelva
ltssdkntwmelleeavrna

Sequence, based on observed residues (ATOM records):

>d3t06a2 b.55.1.1 (A:942-1081) Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF {Human (Homo sapiens) [TaxId: 9606]}
atalerasnplaaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqde
klllkctfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmell
eeavrna

Timeline for d3t06a2:

• d3t06a2 first appeared in SCOPe 2.03
  
• d3t06a2 appears in SCOPe 2.05
  
• d3t06a2 appears in the current release, SCOPe 2.08