SCOPe 2.06: Domain d3qgwb_: 3qgw B:

Lineage for d3qgwb_ (3qgw B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111195] (33 PDB entries)
   Uniprot Q08881 357-619

8. Domain d3qgwb_: 3qgw B: [233324]
   automated match to d4kioc_
   complexed with l7a, pqc

Details for d3qgwb_

PDB Entry: 3qgw, 2.1 Å

PDB Description: Crystal Structure of ITK kinase bound to an inhibitor

PDB Compounds: (B:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d3qgwb_:

Sequence, based on SEQRES records:

>d3qgwb_ d.144.1.7 (B:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
idpseltfvqeigsgqfglvhlgywlnkdkvaiktikegsmseddfieeaevmmklshpk
lvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeac
vihrdlaarnclvgenqvikvsdfgmtrfvlddqytsstgtkfpvkwaspevfsfsryss
ksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhcwke
rpedrpafsrllrqlaeia

Sequence, based on observed residues (ATOM records):

>d3qgwb_ d.144.1.7 (B:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
idpseltfvqeigsgqfglvhlgywlnkdkvaiktikegsmseddfieeaevmmklshpk
lvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeac
vihrdlaarnclvgenqvikvsdfpvkwaspevfsfsryssksdvwsfgvlmwevfsegk
ipyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaeia

Timeline for d3qgwb_:

• d3qgwb_ first appeared in SCOPe 2.03
  
• d3qgwb_ appears in SCOPe 2.05
  
• d3qgwb_ appears in SCOPe 2.07
  
• d3qgwb_ appears in the current release, SCOPe 2.08