SCOPe 2.06: Domain d3nrra2: 3nrr A:205-511

Lineage for d3nrra2 (3nrr A:205-511)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.0: automated matches [227244] (1 protein)
   not a true family

6. Protein automated matches [227010] (5 species)
   not a true protein

7. Species Babesia bovis [TaxId:5865] [233034] (1 PDB entry)

8. Domain d3nrra2: 3nrr A:205-511 [233035]
   Other proteins in same PDB: d3nrra1, d3nrrb1
   automated match to d1qzfa2
   complexed with cl, d16, edo, gol, nap, po4, ump

Details for d3nrra2

PDB Entry: 3nrr, 1.8 Å

PDB Description: co-crystal structure of dihydrofolate reductase-thymidylate synthase from babesia bovis with dump, raltitrexed and nadp

PDB Compounds: (A:) dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d3nrra2:

Sequence; same for both SEQRES and ATOM records:

>d3nrra2 d.117.1.0 (A:205-511) automated matches {Babesia bovis [TaxId: 5865]}
gtdisvpkpkyvacpgvrirnheefqyldiladvlshgvlkpnrtgtdayskfgyqmrfd
lsrsfpllttkkvalrsiieellwfikgstngndllaknvriwelngrrdfldkngftdr
eehdlgpiygfqwrhfgaeyldmhadytgkgidqlaeiinriktnpndrrlivcswnvsd
lkkmalppchcffqfyvsdnklscmmhqrscdlglgvpfniasysiltamvaqvcglglg
efvhnladahiyvdhvdavttqiariphpfprlrlnpdirniedftiddivvedyvshpp
ipmamsa

Timeline for d3nrra2:

• d3nrra2 first appeared in SCOPe 2.03
  
• d3nrra2 appears in SCOPe 2.05
  
• d3nrra2 appears in SCOPe 2.07
  
• d3nrra2 appears in the current release, SCOPe 2.08