SCOPe 2.07: Domain d3nfaa_: 3nfa A:

Lineage for d3nfaa_ (3nfa A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (16 families)
   consists of one domain of this fold

5. Family c.55.3.2: Retroviral integrase, catalytic domain [53107] (2 proteins)

6. Protein automated matches [190209] (5 species)
   not a true protein

7. Species Human immunodeficiency virus 1 [TaxId:11676] [186963] (69 PDB entries)

8. Domain d3nfaa_: 3nfa A: [233021]
   automated match to d4ah9a_
   complexed with acy, cbj, so4

Details for d3nfaa_

PDB Entry: 3nfa, 1.95 Å

PDB Description: Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design

PDB Compounds: (A:) integrase

SCOPe Domain Sequences for d3nfaa_:

Sequence, based on SEQRES records:

>d3nfaa_ c.55.3.2 (A:) automated matches {Human immunodeficiency virus 1 [TaxId: 11676]}
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftsttvkaacwwagikqedgipynpqsqgviesmnkelkkiigqvrdqaehlktav
qmavfihnhkrkggiggysagerivdiiatdiq

Sequence, based on observed residues (ATOM records):

>d3nfaa_ c.55.3.2 (A:) automated matches {Human immunodeficiency virus 1 [TaxId: 11676]}
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftsttvkaacwwagikqedgipynpqsqgviesmnkelkkiigqvrdqaehlktav
qmavfihnhkrkgysagerivdiiatdiq

Timeline for d3nfaa_:

• d3nfaa_ first appeared in SCOPe 2.03
  
• d3nfaa_ appears in SCOPe 2.06
  
• d3nfaa_ appears in the current release, SCOPe 2.08