SCOPe 2.03: Domain d3lxka_: 3lxk A:

Lineage for d3lxka_ (3lxk A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d3lxka_: 3lxk A: [232862]
   automated match to d4gmya_
   complexed with mi1

Details for d3lxka_

PDB Entry: 3lxk, 2 Å

PDB Description: structural and thermodynamic characterization of the tyk2 and jak3 kinase domains in complex with cp-690550 and cmp-6

PDB Compounds: (A:) Tyrosine-protein kinase JAK3

SCOPe Domain Sequences for d3lxka_:

Sequence, based on SEQRES records:

>d3lxka_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgcerdvpalsrllell
eegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldml

Sequence, based on observed residues (ATOM records):

>d3lxka_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmvpalsrllelleegqr
lpappacpaevhelmklcwapspqdrpsfsalgpqldml

Timeline for d3lxka_:

• d3lxka_ is new in SCOPe 2.03-stable
  
• d3lxka_ appears in SCOPe 2.04
  
• d3lxka_ appears in the current release, SCOPe 2.08