SCOP 1.75: Domain d1e8za2: 1e8z A:357-522

Lineage for d1e8za2 (1e8z A:357-522)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (2 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (11 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (3 PDB entries)

8. Domain d1e8za2: 1e8z A:357-522 [23188]
   Other proteins in same PDB: d1e8za1, d1e8za3, d1e8za4
   complexed with stu; mutant

Details for d1e8za2

PDB Entry: 1e8z, 2.4 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine

PDB Compounds: (A:) phosphatidylinositol 3-kinase catalytic subunit

SCOP Domain Sequences for d1e8za2:

Sequence, based on SEQRES records:

>d1e8za2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
cdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycgkapalsskasaespsseskgkvrllyyvnlllidhrfllr
rgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilldn

Sequence, based on observed residues (ATOM records):

>d1e8za2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
cdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatn
pdkensmsisilldn

Timeline for d1e8za2:

• d1e8za2 first appeared (with stable ids) in SCOP 1.55
  
• d1e8za2 appears in SCOP 1.73
  
• d1e8za2 appears in SCOPe 2.01
  
• d1e8za2 appears in the current release, SCOPe 2.08