SCOP 1.71: Domain d1e8wa2: 1e8w A:352-524

Lineage for d1e8wa2 (1e8w A:352-524)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.7: C2 domain-like [49561] (4 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (2 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (6 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [49571] (5 PDB entries)

8. Domain d1e8wa2: 1e8w A:352-524 [23186]
   Other proteins in same PDB: d1e8wa1, d1e8wa3, d1e8wa4
   complexed with que; mutant

Details for d1e8wa2

PDB Entry: 1e8w, 2.5 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine

SCOP Domain Sequences for d1e8wa2:

Sequence, based on SEQRES records:

>d1e8wa2 b.7.1.1 (A:352-524) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa)}
vslwdcdrkfrvkirgidipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwn
vwlefsikikdlpkgallnlqiycgkapalsgktsaempspeskgkaqllyyvnlllidh
rfllrhgeyvlhmwqlsgkgedqgsfnadkltsatnpdkensmsisilldnyc

Sequence, based on observed residues (ATOM records):

>d1e8wa2 b.7.1.1 (A:352-524) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa)}
vslwdcdrkfrvkirgidipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwn
vwlefsikikdlpkgallnlqiycgqllyyvnlllidhrfllrhgeyvlhmwqlsfnadk
ltsatnpdkensmsisilldnyc

Timeline for d1e8wa2:

• d1e8wa2 first appeared (with stable ids) in SCOP 1.55
  
• d1e8wa2 appears in SCOP 1.69
  
• d1e8wa2 appears in SCOP 1.73
  
• d1e8wa2 appears in the current release, SCOPe 2.08