SCOP 1.73: Domain d1e8xa2: 1e8x A:357-522

Lineage for d1e8xa2 (1e8x A:357-522)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.7: C2 domain-like [49561] (4 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (2 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (8 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [49571] (5 PDB entries)

8. Domain d1e8xa2: 1e8x A:357-522 [23183]
   Other proteins in same PDB: d1e8xa1, d1e8xa3, d1e8xa4
   complexed with atp, lu; mutant

Details for d1e8xa2

PDB Entry: 1e8x, 2.2 Å

PDB Description: structural insights into phoshoinositide 3-kinase enzymatic mechanism and signalling

PDB Compounds: (A:) phosphatidylinositol 3-kinase catalytic subunit

SCOP Domain Sequences for d1e8xa2:

Sequence, based on SEQRES records:

>d1e8xa2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa) [TaxId: 9823]}
cdrkfrvkirgidipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycgkapalsgktsaempspeskgkaqllyyvnlllidhrfllr
hgeyvlhmwqlsgkgedqgsfnadkltsatnpdkensmsisilldn

Sequence, based on observed residues (ATOM records):

>d1e8xa2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa) [TaxId: 9823]}
cdrkfrvkirgidipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycqllyyvnlllidhrfllrhgeyvlhmwqlsgfnadkltsat
npdkensmsisilldn

Timeline for d1e8xa2:

• d1e8xa2 first appeared (with stable ids) in SCOP 1.55
  
• d1e8xa2 appears in SCOP 1.71
  
• d1e8xa2 appears in SCOP 1.75
  
• d1e8xa2 appears in the current release, SCOPe 2.08