SCOPe 2.08: Domain d2wvjc1: 2wvj C:18-150

Lineage for d2wvjc1 (2wvj C:18-150)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.24: Type II thymidine kinase [117558] (2 proteins)
   N-terminal part of Pfam PF00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (52684)

6. Protein automated matches [230352] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [230353] (2 PDB entries)

8. Domain d2wvjc1: 2wvj C:18-150 [231521]
   Other proteins in same PDB: d2wvja2, d2wvjb2, d2wvjc2, d2wvjd2, d2wvje2, d2wvjf2, d2wvjg2, d2wvjh2
   automated match to d1xbta1
   complexed with mg, ttp, zn; mutant

Details for d2wvjc1

PDB Entry: 2wvj, 2.2 Å

PDB Description: mutation of thr163 to ser in human thymidine kinase shifts the specificity from thymidine towards the nucleoside analogue azidothymidine

PDB Compounds: (C:) Thymidine kinase, cytosolic

SCOPe Domain Sequences for d2wvjc1:

Sequence, based on SEQRES records:

>d2wvjc1 c.37.1.24 (C:18-150) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrysssfcthdrntmealp
acllrdvaqealgvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgail
nlvplaesvvklt

Sequence, based on observed residues (ATOM records):

>d2wvjc1 c.37.1.24 (C:18-150) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtralpacllrdvaqealgv
avigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklt

Timeline for d2wvjc1:

• d2wvjc1 first appeared in SCOPe 2.03
  
• d2wvjc1 appears in SCOPe 2.07