SCOPe 2.05: Domain d2pvyc_: 2pvy C:

Lineage for d2pvyc_ (2pvy C:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 2 [75562] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [75563] (16 PDB entries)
   Uniprot P21802 467-765

8. Domain d2pvyc_: 2pvy C: [231175]
   automated match to d2pvyb_
   complexed with acp, so4; mutant

Details for d2pvyc_

PDB Entry: 2pvy, 2.2 Å

PDB Description: crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k659n mutation responsible for an unclassified craniosynostosis syndrome.

PDB Compounds: (C:) Fibroblast growth factor receptor 2

SCOPe Domain Sequences for d2pvyc_:

Sequence, based on SEQRES records:

>d2pvyc_ d.144.1.7 (C:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
gvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkd
datekdlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrp
pgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmk
iadfglardinnidyyknttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlgg
spypgipveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldril
tlt

Sequence, based on observed residues (ATOM records):

>d2pvyc_ d.144.1.7 (C:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
gvseyelpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddatekd
lsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmevp
eeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinny
ykngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeg
hrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Timeline for d2pvyc_:

• d2pvyc_ first appeared in SCOPe 2.03
  
• d2pvyc_ appears in SCOPe 2.04
  
• d2pvyc_ appears in SCOPe 2.06
  
• d2pvyc_ appears in the current release, SCOPe 2.08