SCOPe 2.06: Domain d2pvya_: 2pvy A:

Lineage for d2pvya_ (2pvy A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 2 [75562] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [75563] (16 PDB entries)
   Uniprot P21802 467-765

8. Domain d2pvya_: 2pvy A: [231173]
   automated match to d2pvyb_
   complexed with acp, so4; mutant

Details for d2pvya_

PDB Entry: 2pvy, 2.2 Å

PDB Description: crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k659n mutation responsible for an unclassified craniosynostosis syndrome.

PDB Compounds: (A:) Fibroblast growth factor receptor 2

SCOPe Domain Sequences for d2pvya_:

Sequence, based on SEQRES records:

>d2pvya_ d.144.1.7 (A:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
elpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatek
dlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmey
sydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfg
lardinnidyyknttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypg
ipveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Sequence, based on observed residues (ATOM records):

>d2pvya_ d.144.1.7 (A:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
elpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddatekdlsdlv
sememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmdinrvpee
qmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidy
yknttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkll
keghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Timeline for d2pvya_:

• d2pvya_ first appeared in SCOPe 2.03
  
• d2pvya_ appears in SCOPe 2.05
  
• d2pvya_ appears in SCOPe 2.07
  
• d2pvya_ appears in the current release, SCOPe 2.08