SCOPe 2.03: Domain d2jleb_: 2jle B:

Lineage for d2jleb_ (2jle B:)

1. Root: SCOPe 2.03

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein automated matches [190211] (5 species)
   not a true protein

7. Species Human immunodeficiency virus 1 [TaxId:11676] [186967] (5 PDB entries)

8. Domain d2jleb_: 2jle B: [230920]
   Other proteins in same PDB: d2jlea2
   automated match to d2jlea1
   complexed with i15

Details for d2jleb_

PDB Entry: 2jle, 2.9 Å

PDB Description: novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays

PDB Compounds: (B:) Reverse transcriptase/RNaseH

SCOPe Domain Sequences for d2jleb_:

Sequence, based on SEQRES records:

>d2jleb_ e.8.1.2 (B:) automated matches {Human immunodeficiency virus 1 [TaxId: 11676]}
spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfa
ikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplde
dfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyq
ymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvq
pivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaele
laenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgaht
ndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntppl
vklwyqle

Sequence, based on observed residues (ATOM records):

>d2jleb_ e.8.1.2 (B:) automated matches {Human immunodeficiency virus 1 [TaxId: 11676]}
spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfa
ikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplde
dfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyq
ymddlyvgsdleigqhrtkieelrqhllrwglttpmgyelhpdkwtvqpivlpekdswtv
ndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepv
hgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqk
ittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqle

Timeline for d2jleb_:

• d2jleb_ is new in SCOPe 2.03-stable
  
• d2jleb_ appears in SCOPe 2.04
  
• d2jleb_ appears in the current release, SCOPe 2.08