SCOPe 2.06: Domain d4iskc1: 4isk C:2-264

Lineage for d4iskc1 (4isk C:2-264)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Escherichia coli [TaxId:562] [55834] (67 PDB entries)

8. Domain d4iskc1: 4isk C:2-264 [230058]
   Other proteins in same PDB: d4iska2, d4iskb2, d4iskc2, d4iskd2, d4iske2, d4iskf2, d4iskg2, d4iskh2
   automated match to d1f4ba_
   complexed with 1jy, mg, umc, ump

Details for d4iskc1

PDB Entry: 4isk, 1.75 Å

PDB Description: Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor

PDB Compounds: (C:) Thymidylate synthase

SCOPe Domain Sequences for d4iskc1:

Sequence; same for both SEQRES and ATOM records:

>d4iskc1 d.117.1.1 (C:2-264) Thymidylate synthase {Escherichia coli [TaxId: 562]}
kqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihellw
flqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlkn
dpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfniasy
allvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesifd
yrfedfeiegydphpgikapvai

Timeline for d4iskc1:

• d4iskc1 first appeared in SCOPe 2.03, called d4iskc_
  
• d4iskc1 was called d4iskc_ in SCOPe 2.05
  
• d4iskc1 appears in SCOPe 2.07
  
• d4iskc1 appears in the current release, SCOPe 2.08