SCOPe 2.08: Domain d4nksb_: 4nks B:

Lineage for d4nksb_ (4nks B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (47 PDB entries)

8. Domain d4nksb_: 4nks B: [229981]
   automated match to d4f63b_
   complexed with 2m2

Details for d4nksb_

PDB Entry: 4nks, 2.5 Å

PDB Description: Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 3

PDB Compounds: (B:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d4nksb_:

Sequence, based on SEQRES records:

>d4nksb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksda
tekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppg
leysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkia
dfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggsp
ypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrival
t

Sequence, based on observed residues (ATOM records):

>d4nksb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
seyelpedprwelprdrlvlgkplgegagqvvlaeaiglpnrvtkvavkmlksdatekdl
sdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrqlsskdlv
scayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgladyykkgrlpvkwmape
alfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnely
mmmrdcwhavpsqrptfkqlvedldrivalt

Timeline for d4nksb_:

• d4nksb_ first appeared in SCOPe 2.03
  
• d4nksb_ appears in SCOPe 2.07