SCOPe 2.06: Domain d4cfwa1: 4cfw A:1-298

Lineage for d4cfwa1 (4cfw A:1-298)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (374 PDB entries)
   Uniprot P24941

8. Domain d4cfwa1: 4cfw A:1-298 [229804]
   Other proteins in same PDB: d4cfwa2, d4cfwb1, d4cfwb2, d4cfwc2, d4cfwd1, d4cfwd2
   automated match to d1h27a_
   complexed with sq9

Details for d4cfwa1

PDB Entry: 4cfw, 2.45 Å

PDB Description: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4cfwa1:

Sequence; same for both SEQRES and ATOM records:

>d4cfwa1 d.144.1.7 (A:1-298) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d4cfwa1:

• d4cfwa1 first appeared in SCOPe 2.03, called d4cfwa_
  
• d4cfwa1 was called d4cfwa_ in SCOPe 2.05
  
• d4cfwa1 appears in SCOPe 2.07
  
• d4cfwa1 appears in the current release, SCOPe 2.08