SCOPe 2.07: Domain d4ca5a_: 4ca5 A:

Lineage for d4ca5a_ (4ca5 A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
   combines M2, M3 and M32 families of metalloproteases
   the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

6. Protein Angiotensin converting enzyme, ACE [82733] (2 species)
   M2 family member; overall fold is similar to that of neurolysin but is less elaborated

7. Species Human (Homo sapiens) [TaxId:9606] [82734] (11 PDB entries)
   Uniprot P22966

8. Domain d4ca5a_: 4ca5 A: [229564]
   automated match to d1uzea_
   complexed with 3ef, act, cl, nag, peg, zn

Details for d4ca5a_

PDB Entry: 4ca5, 1.85 Å

PDB Description: human angiotensin converting enzyme in complex with a phosphinic tripeptide fi

PDB Compounds: (A:) angiotensin-converting enzyme

SCOPe Domain Sequences for d4ca5a_:

Sequence; same for both SEQRES and ATOM records:

>d4ca5a_ d.92.1.5 (A:) Angiotensin converting enzyme, ACE {Human (Homo sapiens) [TaxId: 9606]}
deaeaskfveeydrtsqvvwneyaeanwnyntnittetskillqknmqianhtlkygtqa
rkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpngscl
qlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvdagds
wrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllgnmw
aqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefwnks
mlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykdlpv
alreganpgfheaigdvlalsvstpkhlhslnllsseggsdehdinflmkmaldkiafip
fsylvdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhipssvp
yiryfvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpeamq
litgqpnmsasamlsyfkplldwlrtenelhgeklgwpqynwtpns

Timeline for d4ca5a_:

• d4ca5a_ first appeared in SCOPe 2.03
  
• d4ca5a_ appears in SCOPe 2.06
  
• d4ca5a_ appears in the current release, SCOPe 2.08