SCOPe 2.08: Domain d4mdna1: 4mdn A:18-110

Lineage for d4mdna1 (4mdn A:18-110)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
   core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
   duplication: consists of two structural repeats

4. Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families)
   binds to the transactivation domain of human p53

5. Family a.42.1.1: SWIB/MDM2 domain [47593] (5 proteins)
   Pfam PF02201

6. Protein MDM2 [47594] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47596] (76 PDB entries)

8. Domain d4mdna1: 4mdn A:18-110 [229496]
   Other proteins in same PDB: d4mdna2
   automated match to d3lbla_
   complexed with so4, y30

Details for d4mdna1

PDB Entry: 4mdn, 1.91 Å

PDB Description: Structure of a novel submicromolar MDM2 inhibitor

PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d4mdna1:

Sequence; same for both SEQRES and ATOM records:

>d4mdna1 a.42.1.1 (A:18-110) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
qipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
sndllgdlfgvpsfsvkehrkiytmiyrnlvvv

Timeline for d4mdna1:

• d4mdna1 first appeared in SCOPe 2.03, called d4mdna_
  
• d4mdna1 appears in SCOPe 2.07