SCOPe 2.08: Domain d4mxza_: 4mxz A:

Lineage for d4mxza_ (4mxz A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-src tyrosine kinase [56155] (3 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56156] (14 PDB entries)

8. Domain d4mxza_: 4mxz A: [229459]
   automated match to d3en6b_
   complexed with db8; mutant

Details for d4mxza_

PDB Entry: 4mxz, 2.58 Å

PDB Description: Src M314L T338M double mutant bound to kinase inhibitor bosutinib

PDB Compounds: (A:) Proto-oncogene tyrosine-protein kinase Src

SCOPe Domain Sequences for d4mxza_:

Sequence, based on SEQRES records:

>d4mxza_ d.144.1.7 (A:) c-src tyrosine kinase {Human (Homo sapiens) [TaxId: 9606]}
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvlkk
lrheklvqlyavvseepiyivmeymskgslldflkgetgkylrlpqlvdmaaqiasgmay
vermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaaly
grftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmc
qcwrkepeerptfeylqafledyftstepqyqpgenl

Sequence, based on observed residues (ATOM records):

>d4mxza_ d.144.1.7 (A:) c-src tyrosine kinase {Human (Homo sapiens) [TaxId: 9606]}
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvlkk
lrheklvqlyavvseepiyivmeymskgslldflkgetgkylrlpqlvdmaaqiasgmay
vermnyvhrdlraanilvgenlvckvadfglarliefpikwtapeaalygrftiksdvws
fgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkepeerp
tfeylqafledyftstepqyqpgenl

Timeline for d4mxza_:

• d4mxza_ first appeared in SCOPe 2.03
  
• d4mxza_ appears in SCOPe 2.07