SCOPe 2.08: Domain d4c4ea1: 4c4e A:519-794

Lineage for d4c4ea1 (4c4e A:519-794)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4c4ea1: 4c4e A:519-794 [229416]
   Other proteins in same PDB: d4c4ea2
   automated match to d3ceka_
   complexed with 1pe, 4t9, 7pe

Details for d4c4ea1

PDB Entry: 4c4e, 2.6 Å

PDB Description: Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1

PDB Compounds: (A:) Dual specificity protein kinase TTK

SCOPe Domain Sequences for d4c4ea1:

Sequence, based on SEQRES records:

>d4c4ea1 d.144.1.0 (A:519-794) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiaylnkl
qqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleavhti
hqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppeaikdm
sssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnheiefpd
ipekdlqdvlkcclkrdpkqrisipellahpyvqiq

Sequence, based on observed residues (ATOM records):

>d4c4ea1 d.144.1.0 (A:519-794) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiaylnkl
qqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleavhti
hqhgivhsdlkpanflivdgmlklidfgianqmqpqvgtvnymppeaikdispksdvwsl
gcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpkqri
sipellahpyvqiq

Timeline for d4c4ea1:

• d4c4ea1 first appeared in SCOPe 2.03, called d4c4ea_
  
• d4c4ea1 appears in SCOPe 2.07