Lineage for d4hvba4 (4hvb A:726-1090)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542186Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)
  6. 2542190Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)
  7. 2542191Species Human (Homo sapiens) [TaxId:9606] [56174] (72 PDB entries)
  8. 2542236Domain d4hvba4: 4hvb A:726-1090 [229092]
    Other proteins in same PDB: d4hvba1, d4hvba2, d4hvba3
    automated match to d1e8ya4
    complexed with 19p

Details for d4hvba4

PDB Entry: 4hvb (more details), 2.35 Å

PDB Description: Catalytic unit of PI3Kg in complex with PI3K/mTOR dual inhibitor PF-04979064
PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4hvba4:

Sequence, based on SEQRES records: (download)

>d4hvba4 d.144.1.4 (A:726-1090) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhl

Sequence, based on observed residues (ATOM records): (download)

>d4hvba4 d.144.1.4 (A:726-1090) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsssqvisqlkqklenlqnsqlpesfrvpydpgl
kagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrim
esiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwl
kekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgn
yvpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpq
ltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhl

SCOPe Domain Coordinates for d4hvba4:

Click to download the PDB-style file with coordinates for d4hvba4.
(The format of our PDB-style files is described here.)

Timeline for d4hvba4: