SCOPe 2.06: Domain d4hvba2: 4hvb A:357-522

Lineage for d4hvba2 (4hvb A:357-522)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (61 PDB entries)

8. Domain d4hvba2: 4hvb A:357-522 [229090]
   Other proteins in same PDB: d4hvba1, d4hvba3, d4hvba4
   automated match to d1e8ya2
   complexed with 19p

Details for d4hvba2

PDB Entry: 4hvb, 2.35 Å

PDB Description: Catalytic unit of PI3Kg in complex with PI3K/mTOR dual inhibitor PF-04979064

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4hvba2:

Sequence, based on SEQRES records:

>d4hvba2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
cdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycgkapalsskasaespsseskgkvrllyyvnlllidhrfllr
rgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilldn

Sequence, based on observed residues (ATOM records):

>d4hvba2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
cdrkfrvkirgidipvlltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikik
dlpkgallnlqiycllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdken
smsisilldn

Timeline for d4hvba2:

• d4hvba2 first appeared in SCOPe 2.03
  
• d4hvba2 appears in SCOPe 2.05
  
• d4hvba2 appears in SCOPe 2.07
  
• d4hvba2 appears in the current release, SCOPe 2.08