SCOPe 2.07: Domain d4i0sa1: 4i0s A:363-635

Lineage for d4i0sa1 (4i0s A:363-635)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase SYK [118131] (1 species)
   PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118132] (73 PDB entries)
   Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)

8. Domain d4i0sa1: 4i0s A:363-635 [228656]
   Other proteins in same PDB: d4i0sa2
   automated match to d1xbba_
   complexed with 1b5

Details for d4i0sa1

PDB Entry: 4i0s, 1.98 Å

PDB Description: crystal structure of spleen tyrosine kinase complexed with 2-(6- chloro-1-methyl-1h-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7- carboxylic acid isopropylamide

PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d4i0sa1:

Sequence, based on SEQRES records:

>d4i0sa1 d.144.1.7 (A:363-635) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaean
vmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgm
kyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyape
cinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremy
dlmnlcwtydvenrpgfaavelrlrnyyydvvn

Sequence, based on observed residues (ATOM records):

>d4i0sa1 d.144.1.7 (A:363-635) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqqld
npyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylees
nfvhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfssk
sdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtyd
venrpgfaavelrlrnyyydvvn

Timeline for d4i0sa1:

• d4i0sa1 first appeared in SCOPe 2.03, called d4i0sa_
  
• d4i0sa1 appears in SCOPe 2.06
  
• d4i0sa1 appears in the current release, SCOPe 2.08