SCOPe 2.06: Domain d3wd9b_: 3wd9 B:

Lineage for d3wd9b_ (3wd9 B:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48549] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48550] (30 PDB entries)
   Uniprot Q07343 324-667

8. Domain d3wd9b_: 3wd9 B: [228567]
   automated match to d3w5ea_
   complexed with ca, qpc, zn

Details for d3wd9b_

PDB Entry: 3wd9, 2.5 Å

PDB Description: crystal structure of phosphodiesterase 4b in complex with compound 10f

PDB Compounds: (B:) cAMP-specific 3',5'-cyclic phosphodiesterase 4B

SCOPe Domain Sequences for d3wd9b_:

Sequence, based on SEQRES records:

>d3wd9b_ a.211.1.2 (B:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
srfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfriss
dtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaai
hdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqt
lrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadl
snptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhp
lwetwadlvqpdaqdildtlednrnwyqsmipqspsppldeqnrdcqglmekfqfelt

Sequence, based on observed residues (ATOM records):

>d3wd9b_ a.211.1.2 (B:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
srfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfriss
dtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaai
hdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqt
lrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadl
snptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhp
lwetwadlvqpdaqdildtlednrnwyqsmipcqglmekfqfelt

Timeline for d3wd9b_:

• d3wd9b_ first appeared in SCOPe 2.03
  
• d3wd9b_ appears in SCOPe 2.05
  
• d3wd9b_ appears in SCOPe 2.07
  
• d3wd9b_ appears in the current release, SCOPe 2.08