Lineage for d4m6la_ (4m6l A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)
  8. 2137094Domain d4m6la_: 4m6l A: [228388]
    automated match to d1mvta_
    complexed with 21v, dtt, nap, so4

Details for d4m6la_

PDB Entry: 4m6l (more details), 1.7 Å

PDB Description: Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and 5,10-dideazatetrahydrofolic acid
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4m6la_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4m6la_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

SCOPe Domain Coordinates for d4m6la_:

Click to download the PDB-style file with coordinates for d4m6la_.
(The format of our PDB-style files is described here.)

Timeline for d4m6la_: