Lineage for d4m6ja_ (4m6j A:)

  1. Root: SCOPe 2.06
  2. 2089713Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2153715Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2153716Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2153717Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 2153920Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2153968Species Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)
  8. 2153976Domain d4m6ja_: 4m6j A: [228387]
    automated match to d1mvta_
    complexed with ndp

Details for d4m6ja_

PDB Entry: 4m6j (more details), 1.2 Å

PDB Description: Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4m6ja_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4m6ja_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
slncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsipe
knrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssvyk
eamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfevy
eknd

SCOPe Domain Coordinates for d4m6ja_:

Click to download the PDB-style file with coordinates for d4m6ja_.
(The format of our PDB-style files is described here.)

Timeline for d4m6ja_: