SCOPe 2.07: Domain d4keba_: 4keb A:

Lineage for d4keba_ (4keb A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (79 PDB entries)

8. Domain d4keba_: 4keb A: [228213]
   automated match to d1kmva_
   complexed with 1qz, fol, ndp

Details for d4keba_

PDB Entry: 4keb, 1.45 Å

PDB Description: Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4keba_:

Sequence; same for both SEQRES and ATOM records:

>d4keba_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d4keba_:

• d4keba_ first appeared in SCOPe 2.03
  
• d4keba_ appears in SCOPe 2.06
  
• d4keba_ appears in the current release, SCOPe 2.08