SCOPe 2.03: Domain d4kd7a_: 4kd7 A:

Lineage for d4kd7a_ (4kd7 A:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (61 PDB entries)

8. Domain d4kd7a_: 4kd7 A: [228211]
   automated match to d1kmva_
   complexed with 9dr, ndp, so4

Details for d4kd7a_

PDB Entry: 4kd7, 2.71 Å

PDB Description: Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4kd7a_:

Sequence; same for both SEQRES and ATOM records:

>d4kd7a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d4kd7a_:

• d4kd7a_ is new in SCOPe 2.03-stable
  
• d4kd7a_ appears in SCOPe 2.04
  
• d4kd7a_ appears in the current release, SCOPe 2.08