Lineage for d4kd7b_ (4kd7 B:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (63 PDB entries)
  8. 2137131Domain d4kd7b_: 4kd7 B: [228210]
    automated match to d1kmva_
    complexed with 9dr, ndp, so4

Details for d4kd7b_

PDB Entry: 4kd7 (more details), 2.71 Å

PDB Description: Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine
PDB Compounds: (B:) dihydrofolate reductase

SCOPe Domain Sequences for d4kd7b_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4kd7b_ c.71.1.1 (B:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4kd7b_:

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Timeline for d4kd7b_: