SCOPe 2.06: Domain d4kbna_: 4kbn A:

Lineage for d4kbna_ (4kbn A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)

8. Domain d4kbna_: 4kbn A: [228209]
   automated match to d1kmva_
   complexed with 25u, cl, eoh, mg, ndp, nh4, sr

Details for d4kbna_

PDB Entry: 4kbn, 1.84 Å

PDB Description: human dihydrofolate reductase complexed with NADPH and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4kbna_:

Sequence; same for both SEQRES and ATOM records:

>d4kbna_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d4kbna_:

• d4kbna_ first appeared in SCOPe 2.03
  
• d4kbna_ appears in SCOPe 2.05
  
• d4kbna_ appears in SCOPe 2.07
  
• d4kbna_ appears in the current release, SCOPe 2.08