SCOPe 2.07: Domain d4kbnb_: 4kbn B:

Lineage for d4kbnb_ (4kbn B:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (79 PDB entries)

8. Domain d4kbnb_: 4kbn B: [228208]
   automated match to d1kmva_
   complexed with 25u, cl, eoh, mg, ndp, nh4, sr

Details for d4kbnb_

PDB Entry: 4kbn, 1.84 Å

PDB Description: human dihydrofolate reductase complexed with NADPH and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine

PDB Compounds: (B:) dihydrofolate reductase

SCOPe Domain Sequences for d4kbnb_:

Sequence; same for both SEQRES and ATOM records:

>d4kbnb_ c.71.1.1 (B:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d4kbnb_:

• d4kbnb_ first appeared in SCOPe 2.03
  
• d4kbnb_ appears in SCOPe 2.06
  
• d4kbnb_ appears in the current release, SCOPe 2.08