SCOPe 2.03: Domain d4c67a_: 4c67 A:

Lineage for d4c67a_ (4c67 A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (145 PDB entries)

8. Domain d4c67a_: 4c67 A: [228023]
   automated match to d3p5oa_
   complexed with edo, l5s

Details for d4c67a_

PDB Entry: 4c67, 1.55 Å

PDB Description: Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d4c67a_:

Sequence; same for both SEQRES and ATOM records:

>d4c67a_ a.29.2.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

Timeline for d4c67a_:

• d4c67a_ is new in SCOPe 2.03-stable
  
• d4c67a_ appears in SCOPe 2.04
  
• d4c67a_ appears in the current release, SCOPe 2.08, called d4c67a1