SCOPe 2.08: Domain d4lc7a1: 4lc7 A:58-453

Lineage for d4lc7a1 (4lc7 A:58-453)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4lc7a1: 4lc7 A:58-453 [227976]
   Other proteins in same PDB: d4lc7a2
   automated match to d4hzta_
   complexed with 1wp, ni

Details for d4lc7a1

PDB Entry: 4lc7, 1.7 Å

PDB Description: Aminooxazoline inhibitor of BACE-1

PDB Compounds: (A:) Beta-Secretase-1

SCOPe Domain Sequences for d4lc7a1:

Sequence; same for both SEQRES and ATOM records:

>d4lc7a1 b.50.1.2 (A:58-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgynipqtdes

Timeline for d4lc7a1:

• d4lc7a1 first appeared in SCOPe 2.03, called d4lc7a_
  
• d4lc7a1 appears in SCOPe 2.07