Lineage for d4k33a_ (4k33 A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2545120Protein automated matches [190091] (19 species)
    not a true protein
  7. 2545220Species Human (Homo sapiens) [TaxId:9606] [188447] (741 PDB entries)
  8. 2545828Domain d4k33a_: 4k33 A: [227891]
    automated match to d3b2tb_
    complexed with acp, mg; mutant

Details for d4k33a_

PDB Entry: 4k33 (more details), 2.34 Å

PDB Description: crystal structure of fgf receptor 3 (fgfr3) kinase domain harboring the k650e mutation, a gain-of-function mutation responsible for thanatophoric dysplasia type ii and spermatocytic seminoma
PDB Compounds: (A:) Fibroblast growth factor receptor 3

SCOPe Domain Sequences for d4k33a_:

Sequence, based on SEQRES records: (download)

>d4k33a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lpadpkwelsrarltlgkplgegafgqvvmaeaigidkdraakpvtvavkmlkddatdkd
lsdlvsememmkmigkhkniinllgactqggplyvlveyaakgnlreflrarrppgldys
fdtskppeeqltfkdlvscayqvargmeylasqkcihrdlaarnvlvtednvmkiadfgl
ardvhnldyykettngrlpvkwmapealfdrvythqsdvwsfgvllweiftlggspypgi
pveelfkllkeghrmdkpancthdlymimrecwhaapsqrptfkqlvedldrvltvt

Sequence, based on observed residues (ATOM records): (download)

>d4k33a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lpadpkwelsrarltlgkplgegafgqvvmaeaigidkdraakpvtvavkmlkddatdkd
lsdlvsememmkmigkhkniinllgactqggplyvlveyaakgnlreflrarrppgldys
fdtseqltfkdlvscayqvargmeylasqkcihrdlaarnvlvtednvmkiadfglardv
hnldyykettngrlpvkwmapealfdrvythqsdvwsfgvllweiftlggspypgipvee
lfkllkeghrmdkpancthdlymimrecwhaapsqrptfkqlvedldrvltvt

SCOPe Domain Coordinates for d4k33a_:

Click to download the PDB-style file with coordinates for d4k33a_.
(The format of our PDB-style files is described here.)

Timeline for d4k33a_: