SCOPe 2.08: Domain d4gu6b_: 4gu6 B:

Lineage for d4gu6b_ (4gu6 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Focal adhesion kinase 1 (fak) [103292] (2 species)
   PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103293] (23 PDB entries)

8. Domain d4gu6b_: 4gu6 B: [227710]
   automated match to d3pxka_
   complexed with 10n

Details for d4gu6b_

PDB Entry: 4gu6, 1.95 Å

PDB Description: focal adhesion kinase catalytic domain in complex with n-{3-[(5-cyano-2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-ylamino)- methyl]-pyridin-2-yl}-n-methyl-methanesulfonamide

PDB Compounds: (B:) Focal adhesion kinase 1

SCOPe Domain Sequences for d4gu6b_:

Sequence, based on SEQRES records:

>d4gu6b_ d.144.1.7 (B:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwmapesi
nfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlysl
mtkcwaydpsrrprftelkaqlstileeekaq

Sequence, based on observed residues (ATOM records):

>d4gu6b_ d.144.1.7 (B:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfglsrlpikwmapesinfrrftsasdvwmf
gvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrpr
ftelkaqlstileeekaq

Timeline for d4gu6b_:

• d4gu6b_ first appeared in SCOPe 2.03
  
• d4gu6b_ appears in SCOPe 2.07