SCOPe 2.08: Domain d4jyvh_: 4jyv H:

Lineage for d4jyvh_ (4jyv H:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (90 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d4jyvh_: 4jyv H: [227555]
   Other proteins in same PDB: d4jyvl_
   automated match to d1klih_
   complexed with 1oj, ca, gol, so4

Details for d4jyvh_

PDB Entry: 4jyv, 2.19 Å

PDB Description: structure of factor viia in complex with the inhibitor (2r)-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-2-(isoquinolin-6-ylamino)-n-[(3-sulfamoylphenyl)sulfonyl]ethanamide

PDB Compounds: (H:) Factor VII light chain

SCOPe Domain Sequences for d4jyvh_:

Sequence; same for both SEQRES and ATOM records:

>d4jyvh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Timeline for d4jyvh_:

• d4jyvh_ first appeared in SCOPe 2.03
  
• d4jyvh_ appears in SCOPe 2.07