SCOPe 2.06: Domain d4lmna1: 4lmn A:62-382

Lineage for d4lmna1 (4lmn A:62-382)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (1 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (22 PDB entries)
   Uniprot Q02750 61-381

8. Domain d4lmna1: 4lmn A:62-382 [224705]
   Other proteins in same PDB: d4lmna2
   automated match to d1s9ja_
   complexed with anp, eui, mg

Details for d4lmna1

PDB Entry: 4lmn, 2.8 Å

PDB Description: Crystal Structure of MEK1 kinase bound to GDC0973

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d4lmna1:

Sequence, based on SEQRES records:

>d4lmna1 d.144.1.7 (A:62-382) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
elkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhec
nspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltylr
ekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthys
vqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssyg
mdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafi
krsdaeevdfagwlcstigln

Sequence, based on observed residues (ATOM records):

>d4lmna1 d.144.1.7 (A:62-382) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
elkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhec
nspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltylr
ekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthys
vqsdiwsmglslvemavgrypipppdakelelmfppmaifelldyivnepppklpsgvfs
lefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln

Timeline for d4lmna1:

• d4lmna1 first appeared in SCOPe 2.03, called d4lmna_
  
• d4lmna1 was called d4lmna_ in SCOPe 2.05
  
• d4lmna1 appears in SCOPe 2.07
  
• d4lmna1 appears in the current release, SCOPe 2.08