SCOPe 2.05: Domain d4ke1a_: 4ke1 A:

Lineage for d4ke1a_ (4ke1 A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (258 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4ke1a_: 4ke1 A: [224264]
   automated match to d1w50a_
   complexed with 1r6, gol, iod

Details for d4ke1a_

PDB Entry: 4ke1, 1.91 Å

PDB Description: Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 19

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4ke1a_:

Sequence, based on SEQRES records:

>d4ke1a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d4ke1a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgaasvggsmiiggidhslytgsl
wytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksi
kaasstekfpdgfwtpwnifpvislylmgevtnqsfritilpqqylrpvykfaisqsstg
tvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfvtldmedcgyn

Timeline for d4ke1a_:

• d4ke1a_ first appeared in SCOPe 2.03
  
• d4ke1a_ appears in SCOPe 2.04
  
• d4ke1a_ appears in SCOPe 2.06
  
• d4ke1a_ appears in the current release, SCOPe 2.08