SCOPe 2.08: Domain d4ivcb_: 4ivc B:

Lineage for d4ivcb_ (4ivc B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4ivcb_: 4ivc B: [223422]
   Other proteins in same PDB: d4ivca2
   automated match to d3bhhd_
   complexed with 1j6

Details for d4ivcb_

PDB Entry: 4ivc, 2.35 Å

PDB Description: jak1 kinase (jh1 domain) in complex with the inhibitor (trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)acetonitrile

PDB Compounds: (B:) Tyrosine-protein kinase JAK1

SCOPe Domain Sequences for d4ivcb_:

Sequence, based on SEQRES records:

>d4ivcb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpesggnhiadlkk
eieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknknkinlkqqlkya
vqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdsp
vfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrl
vntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Sequence, based on observed residues (ATOM records):

>d4ivcb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpnhiadlkkeiei
lrnlyhenivkykgictngiklimeflpsgslkeylpknknkinlkqqlkyavqickgmd
ylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapec
lmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegk
rlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Timeline for d4ivcb_:

• d4ivcb_ first appeared in SCOPe 2.03
  
• d4ivcb_ appears in SCOPe 2.07