SCOPe 2.06: Domain d4isea2: 4ise A:219-465

Lineage for d4isea2 (4ise A:219-465)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.1: Actin-like ATPase domain [53067] (16 families)
   duplication contains two domains of this fold

5. Family c.55.1.0: automated matches [227137] (1 protein)
   not a true family

6. Protein automated matches [226839] (52 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [224896] (58 PDB entries)

8. Domain d4isea2: 4ise A:219-465 [223339]
   Other proteins in same PDB: d4isea3
   automated match to d1bdga2
   complexed with 1fw, glc, iod

Details for d4isea2

PDB Entry: 4ise, 1.78 Å

PDB Description: human glucokinase in complex with novel activator (2s)-3-cyclohexyl-2- (6-fluoro-4-oxoquinazolin-3(4h)-yl)-n-(1,3-thiazol-2-yl)propanamide

PDB Compounds: (A:) Glucokinase

SCOPe Domain Sequences for d4isea2:

Sequence, based on SEQRES records:

>d4isea2 c.55.1.0 (A:219-465) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qcevgmivgtgcnacymeemqnvelvegdegrmcvntewgafgdsgeldeflleydrlvd
essanpgqqlyekliggkymgelvrlvllrlvdenllfhgeaseqlrtrgafetrfvsqv
esdtgdrkqiynilstlglrpsttdcdivrracesvstraahmcsaglagvinrmresrs
edvmritvgvdgsvyklhpsfkerfhasvrrltpsceitfieseegsgrgaalvsavack
kacmlgq

Sequence, based on observed residues (ATOM records):

>d4isea2 c.55.1.0 (A:219-465) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qcevgmivgtgcnacymeemqnvelvegdegrmcvntewgafgdsgeldeflleydrlvd
essanpgqqlyekliggkymgelvrlvllrlvdenllfhgeaseqlrtrgafetrfvsqv
esdtgdrkqiynilstlglrpsttdcdivrracesvstraahmcsaglagvinrmresrs
vmritvgvdgsvyklhpsfkerfhasvrrltpsceitfieseegsgrgaalvsavackka
cmlgq

Timeline for d4isea2:

• d4isea2 first appeared in SCOPe 2.03
  
• d4isea2 appears in SCOPe 2.05
  
• d4isea2 appears in SCOPe 2.07
  
• d4isea2 appears in the current release, SCOPe 2.08