SCOPe 2.04: Domain d4ii5c_: 4ii5 C:

Lineage for d4ii5c_ (4ii5 C:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (340 PDB entries)
   Uniprot P24941

8. Domain d4ii5c_: 4ii5 C: [223187]
   Other proteins in same PDB: d4ii5b1, d4ii5b2, d4ii5d1, d4ii5d2
   automated match to d1gz8a_
   complexed with adp, gol, mg

Details for d4ii5c_

PDB Entry: 4ii5, 2.15 Å

PDB Description: structure of pcdk2/cyclina bound to adp and 1 magnesium ion

PDB Compounds: (C:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4ii5c_:

Sequence; same for both SEQRES and ATOM records:

>d4ii5c_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d4ii5c_:

• d4ii5c_ first appeared in SCOPe 2.03
  
• d4ii5c_ appears in SCOPe 2.05
  
• d4ii5c_ appears in the current release, SCOPe 2.08