Lineage for d4ieha_ (4ieh A:)

  1. Root: SCOPe 2.07
  2. 2626587Class f: Membrane and cell surface proteins and peptides [56835] (60 folds)
  3. 2626588Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
    multi-helical domains of various folds which is thought to unfold in the membrane
  4. 2626682Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families) (S)
    PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain
  5. 2626683Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
    Pfam PF00452
  6. 2626883Protein automated matches [190236] (3 species)
    not a true protein
  7. 2626884Species Human (Homo sapiens) [TaxId:9606] [188722] (88 PDB entries)
  8. 2626986Domain d4ieha_: 4ieh A: [223148]
    automated match to d4aq3b_
    complexed with 1e9

Details for d4ieha_

PDB Entry: 4ieh (more details), 2.1 Å

PDB Description: crystal structure of human bcl-2 in complex with a small molecule inhibitor targeting bcl-2 bh3 domain interactions
PDB Compounds: (A:) Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera

SCOPe Domain Sequences for d4ieha_:

Sequence, based on SEQRES records: (download)

>d4ieha_ f.1.4.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhltlrqagddfsrryr
rdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmcvesvnremspl
vdnialwmteylnrhlhtwiqdnggwdafvelygp

Sequence, based on observed residues (ATOM records): (download)

>d4ieha_ f.1.4.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ydnreivmkyihyklsqrgyewdsevvhltlrqagddfsrryrrdfaemssqlhltpfta
rgrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlh
twiqdnggwdafvelygp

SCOPe Domain Coordinates for d4ieha_:

Click to download the PDB-style file with coordinates for d4ieha_.
(The format of our PDB-style files is described here.)

Timeline for d4ieha_: