SCOPe 2.06: Domain d4ibyb_: 4iby B:

Lineage for d4ibyb_ (4iby B:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.2: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (9 superfamilies)
   sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold

4. Superfamily b.2.5: p53-like transcription factors [49417] (8 families)

5. Family b.2.5.2: p53 DNA-binding domain-like [81314] (3 proteins)

6. Protein p53 tumor suppressor, DNA-binding domain [49419] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49420] (40 PDB entries)

8. Domain d4ibyb_: 4iby B: [223117]
   automated match to d2ahia_
   complexed with edo, zn; mutant

Details for d4ibyb_

PDB Entry: 4iby, 1.45 Å

PDB Description: human p53 core domain with hot spot mutation r273h and second-site suppressor mutation s240r

PDB Compounds: (B:) Cellular tumor antigen p53

SCOPe Domain Sequences for d4ibyb_:

Sequence; same for both SEQRES and ATOM records:

>d4ibyb_ b.2.5.2 (B:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnrscmggmnrrpiltiitledssgnllgrnsfevh
vcacpgrdrrteeenl

Timeline for d4ibyb_:

• d4ibyb_ first appeared in SCOPe 2.03
  
• d4ibyb_ appears in SCOPe 2.05
  
• d4ibyb_ appears in SCOPe 2.07
  
• d4ibyb_ appears in the current release, SCOPe 2.08