SCOPe 2.08: Domain d4ibva_: 4ibv A:

Lineage for d4ibva_ (4ibv A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.2: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (9 superfamilies)
   sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold

4. Superfamily b.2.5: p53-like transcription factors [49417] (8 families)

5. Family b.2.5.2: p53 DNA-binding domain-like [81314] (3 proteins)

6. Protein p53 tumor suppressor, DNA-binding domain [49419] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49420] (71 PDB entries)

8. Domain d4ibva_: 4ibv A: [223114]
   automated match to d2ahia_
   protein/DNA complex; complexed with edo, zn; mutant

Details for d4ibva_

PDB Entry: 4ibv, 2.1 Å

PDB Description: human p53 core domain with hot spot mutation r273c and second-site suppressor mutation s240r in sequence-specific complex with dna

PDB Compounds: (A:) Cellular tumor antigen p53

SCOPe Domain Sequences for d4ibva_:

Sequence, based on SEQRES records:

>d4ibva_ b.2.5.2 (A:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnrscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrteeenlrkkg

Sequence, based on observed residues (ATOM records):

>d4ibva_ b.2.5.2 (A:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnrscmggmnrrpiltiitledssgnllgrnsfevcvca
cpgrdrrteeenlrkkg

Timeline for d4ibva_:

• d4ibva_ first appeared in SCOPe 2.03
  
• d4ibva_ appears in SCOPe 2.07