SCOPe 2.08: Domain d4i5na1: 4i5n A:9-589

Lineage for d4i5na1 (4i5n A:9-589)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (28 families)

5. Family a.118.1.2: HEAT repeat [48385] (3 proteins)
   Pfam PF02985
   this is a repeat family; one repeat unit is 1b3u A:295-335 found in domain

6. Protein Constant regulatory domain of protein phosphatase 2a, pr65alpha [48386] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48387] (12 PDB entries)

8. Domain d4i5na1: 4i5n A:9-589 [222944]
   Other proteins in same PDB: d4i5na2, d4i5nc_, d4i5nd2, d4i5nf_
   automated match to d4i5la_
   complexed with ca, mn

Details for d4i5na1

PDB Entry: 4i5n, 2.8 Å

PDB Description: structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation

PDB Compounds: (A:) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

SCOPe Domain Sequences for d4i5na1:

Sequence; same for both SEQRES and ATOM records:

>d4i5na1 a.118.1.2 (A:9-589) Constant regulatory domain of protein phosphatase 2a, pr65alpha {Human (Homo sapiens) [TaxId: 9606]}
slypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevlla
laeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleahf
vplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaask
lgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmptl
rqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvke
fcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllpl
flaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieymp
llagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvla
msgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqkig
pildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

Timeline for d4i5na1:

• d4i5na1 first appeared in SCOPe 2.03, called d4i5na_
  
• d4i5na1 appears in SCOPe 2.07