SCOPe 2.07: Domain d4i12a1: 4i12 A:63-453

Lineage for d4i12a1 (4i12 A:63-453)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4i12a1: 4i12 A:63-453 [222851]
   Other proteins in same PDB: d4i12a2
   automated match to d4i0za_
   complexed with 1bc, na, zn

Details for d4i12a1

PDB Entry: 4i12, 1.78 Å

PDB Description: design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4i12a1:

Sequence, based on SEQRES records:

>d4i12a1 b.50.1.2 (A:63-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
mvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsstyr
dlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegilgl
ayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiiggidh
slytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvf
eaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritil
pqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachv
hdefrtaavegpfvtldmedcgynipqtdes

Sequence, based on observed residues (ATOM records):

>d4i12a1 b.50.1.2 (A:63-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
mvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsstyr
dlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegilgl
ayaeiarpddslepffdslvkqthvpnlfslqlcggsmiiggidhslytgslwytpirre
wyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaasstek
fpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpvtsqddcy
kfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvrtaavegpfvtldmedcgy
nipqtdes

Timeline for d4i12a1:

• d4i12a1 first appeared in SCOPe 2.03, called d4i12a_
  
• d4i12a1 appears in SCOPe 2.06
  
• d4i12a1 appears in the current release, SCOPe 2.08